CHEM222 Organic Chemistry II
Department of Science, Technology, Engineering & Mathematics: Chemistry
- I. Course Number and Title
- CHEM222 Organic Chemistry II
- II. Number of Credits
- 5 credits
- III. Minimum Number of Instructional Minutes Per Semester
- 5250 minutes
- IV. Prerequisites
- CHEM221 (C or better)
- V. Other Pertinent Information
- Three-hour lecture, one-hour lab discussion and three-hour laboratory per week. Safety glasses or goggles required.
- VI. Catalog Course Description
- This course is a continuation of Chemistry 221 with an emphasis on aromatic and carbonyl chemistry. Spectroscopy and chromatography are integrated into the lecture and laboratory. Compounds are analyzed using classical and instrumental methods.
- VII. Required Course Content and Direction
Organic Chemistry II (CHEM 222), along with Organic Chemistry I (CHEM 221), provides the fundamental background in organic chemistry necessary for biology and chemistry majors. It also fulfills the requirements of pre-medical, pre-dental, pharmacy, chiropractic, and chemical engineering schools.
As one of the Natural Sciences, chemistry has evolved out of careful observation and experimentation; as technology evolves, so does the body of chemical knowledge. This course will integrate relevant technological advances and their impact in the formulation of chemical principles and their applications. The laboratory component of the course will help to illustrate and apply some of these technological advances.
The course integrates and complements the information studied in CHEM221, and prepares the student for the study of more advanced topics including polymers, biochemistry, and molecular biology. Emphasis is on aromatic and carbonyl chemistry. Topics include structure, stereochemistry, nomenclature, synthesis, properties and reactions of these compounds.
The laboratory course contains examples of some important synthetic reactions in organic chemistry, as well as a set of experiments aimed at the identification of organic compounds. Both chromatographic techniques and instrumentation are involved, whenever possible, in the execution of these experiments.
- Course Learning Goals
- analyze the structure of organic compounds by recognizing main functional groups, naming the compounds using the I.U.P.A.C system, and predicting their properties using the type of bonding, hybridization state, intermolecular forces, stereochemistry, conjugation, resonance and aromaticity;
- describe mechanisms of reactions: electrophilic aromatic substitution, nucleophilic addition, pericyclic reactions, in addition to those learned in Organic I, and apply this knowledge to predict the major product in organic reactions, such as those involving hydrocarbons, alcohols, alkyl halides and alkenes;
- analyze the nature of a reagent as a nucleophile, free radical, or electrophile and use this knowledge to propose the synthesis of organic compounds, such as hydrocarbons, alkyl halides, alcohols, ethers, alkenes, alkynes, aromatics, amines, and carbonyl containing compounds;
- use the characteristics of the common functional groups to understand the formation and properties of larger molecules, i.e. synthetic polymers and biomolecules: carbohydrates, peptides, and lipids; and
- demonstrate proficiency in organic laboratory skills as they pertain to: chemical information, safe handling, use and disposal of organic compounds; synthetic procedures including isolation, purification and structure elucidation of obtained products, use of multi-step synthesis; stoichiometry and use of instrumentation; and writing of laboratory notebooks and reports in accordance with current scientific journals styles.
- Core Learning Goals (if applicable)
Students will be able to
Planned Sequence of Topics and/or Learning Activities:Course Outline:
- Alkynes: Structure, Nomenclature, Properties, Preparation, and Reactions
- Dienes: Structure, Nomenclature and Reactions, Polymers and Polymerization
- Arenes and Aromaticity: Structure, Nomenclature, and Reactions
- Spectroscopy: NMR, IR, MS, UV
- Organometallic Compounds: Structure, Nomenclature, Preparation, and Reactions
- Alcohols: Preparation and Reactions
- Ethers and Epoxides: Structure, Nomenclature, Preparation, and Reactions
- Aldehydes and Ketones: Structure, Properties, Preparation, Reactions, and Analysis
- Carboxylic Acids: Reactions, Synthesis, and Spectroscopy
- Acyl Transfer Reactions: Carboxylic Acids Derivatives
- Amines: Preparation, Physical Properties, and Reactions
- ARYL HALIDES: Bonding, Reactions, and Mechanisms
- Phenols: Structure, Preparations, Reactions, and Analysis
- Ester Enolates: Condensation Reactions
While specific laboratory experiments vary depending on the instructor and the semester, the following list is representative of the experiments that are used:
- Check-in, Safety Regulations
- Organic Reactions (Computer Program)
- Polymers and Plastics: Polyesters and Polyamide (Nylon)
- Grignard Reaction: Preparation of Benzoic Acid and of Methyl Benzoate
- Nitration of Methyl Benzoate
- Friedel-Crafts Acylation
- Vacuum Distillation FC Product
- Cannizaro Reaction
- Reduction of F.C. Product
- Computer Unknowns Identification
Learning Activities: Instruction aims to enable the student to:
- recognize functional groups in organic compounds;
- name organic compounds using the I.U.P.A.C. system;
- analyze the structure of a given compound and predict the type of bonding, hybridization state, and effect of the structure on the physical properties of such a compound;
- apply the concepts of conjugation, resonance, and aromaticity on the prediction of the behavior of some compounds;
- write and understand mechanisms for the different types of organic reactions: electrophilic aromatic substitution, electrophilic addition, pericyclic reactions, in addition to the ones covered in Organic Chemistry I;
- predict the major product in an organic reaction, such as those involving alkynes, aromatic compounds, carbonyl containing compounds, and amines, by applying the knowledge of reaction mechanisms;
- write a scheme for the synthesis of different classes of organic compounds such as alkynes, ethers, aromatic compounds, amines, and carbonyl containing compounds;
- standardize and operate laboratory instruments to identify reactants and products and to separate mixtures of compounds;
- execute multi-step synthesis in the laboratory; calculate the yield after isolation and purification, identify the products of the reactions by physical, chemical, and spectroscopic tests;
- identify a given organic unknown compound by using physical, chemical, and spectroscopic data;
- prepare laboratory reports in accordance with current scientific journal styles;
- utilize the characteristics of the common functional groups to understand the formation and properties of larger molecules, i.e., synthetic polymers and biomolecules, such as carbohydrates, peptides, and lipids;
- obtain information about chemical compounds from all possible reference sources, apply this information for the safe handling, use and disposal of such compounds in an environmentally responsible manner;
- work as a member of a team in solving classroom problems and in the laboratory; and
- use appropriate current technology in the laboratory to obtain data and understand the impact that this latest technology has on the field.
Assessment Methods for Core Learning Goals:
- Assessment Methods for Course Learning Goals
- Assessment Methods for Core Learning Goals (if applicable)
Course learning goals will be continuously assessed by periodic written examinations, class exercises, laboratory preparation, laboratory results, laboratory reports, and assigned work.
Reference, Resource, or Learning Materials to be used by Students:The students will use approved text, laboratory modules and handouts, laboratory and demonstration equipment, library, science learning center, computer programs, and internet links. Please refer to the course format for specific information.
- VIII. Teaching Methods Employed
- The lecture portion is presented in a lecture/discussion format. The laboratory and lectures are arranged in such a way as to reinforce the topics covered in the course. Both lecture and laboratory are taught by the same instructor. More than one laboratory experiment may be performed during the same lab period. All synthetic procedures include appropriate spectroscopic techniques for structure identification.
Review/Approval Date - 2/99; Revised 6/08